› 2a9i

X-ray diffraction
1.7Å resolution

Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain

Released:
DOI: 10.2210/pdb2a9i/pdb
PDB entry 2a9i coloured by chain, front view.
PDB entry 2a9i coloured by chain, side view.
PDB entry 2a9i coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling.
Lasker MV, Gajjar MM, Nair SK
J Immunol 175 4175-9 (2005)
PMID: 16177054

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185898 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.66 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8R4K2 (Residues: 1-113; Coverage: 25%)
Gene name: Irak4
Structure domains: Death Domain, Fas

Ligands and Environments

1 bound ligand:
Ligand MN 1 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B, APS BEAMLINE 32-ID
Spacegroup: C2
Unit cell:
a: 76.152Å b: 38.043Å c: 51.588Å
α: 90° β: 121.07° γ: 90°
R-values:
R R work R free
0.18 0.177 0.223
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Structure and function of Toll receptors and their ligands.
Gay et al. (2007)
7 more

4 mentions without citation

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
3 more