Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domain:
Structure domain:
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Ubiquitin carboxyl-terminal hydrolase 8 (preferred)
PDBe Complex ID:
PDB-CPX-154192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin carboxyl-terminal hydrolase 8
Molecule details ›
Chains: A, B
Length: 144 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: USP8 dimerisation domain
Structure domains: Phosphotransferase system, lactose/cellobiose-type IIA subunit
Length: 144 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P40818 (Residues: 1-142; Coverage: 13%)
Sequence domains: USP8 dimerisation domain
Structure domains: Phosphotransferase system, lactose/cellobiose-type IIA subunit
