› 2ach

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF CLEAVED HUMAN ALPHA1-ANTICHYMOTRYPSIN AT 2.7 ANGSTROMS RESOLUTION AND ITS COMPARISON WITH OTHER SERPINS

Released:
DOI: 10.2210/pdb2ach/pdb
PDB entry 2ach coloured by chain, front view.
PDB entry 2ach coloured by chain, side view.
PDB entry 2ach coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins.
Baumann U, Huber R, Bode W, Grosse D, Lesjak M, Laurell CB
J Mol Biol 218 595-606 (1991)
PMID: 2016749

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-133792 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Alpha-1-antichymotrypsin Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 40.7 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01011 (Residues: 24-383; Coverage: 90%)
Gene names: AACT, GIG24, GIG25, SERPINA3
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Alpha-1-antichymotrypsin His-Pro-less Chain: B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01011 (Residues: 384-423; Coverage: 10%)
Gene names: AACT, GIG24, GIG25, SERPINA3

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 75.3Å b: 75.3Å c: 208Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.181 not available
Expression system: Not provided

Quick links

Citations

13 review citations

Natural protein proteinase inhibitors and their interaction with proteinases.
Bode et al. (1992)
12 more

6 mentions without citation

Neuroserpin: structure, function, physiology and pathology.
D'Acunto et al. (2021)
5 more