› 2acm

Solution NMR

Solution structure of the SEA domain of human mucin 1 (MUC1)

Released:
DOI: 10.2210/pdb2acm/pdb
PDB entry 2acm coloured by chain, ensemble of 15 models, front view.
PDB entry 2acm coloured by chain, ensemble of 15 models, side view.
PDB entry 2acm coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin.
Macao B, Johansson DG, Hansson GC, Härd T
Nat Struct Mol Biol 13 71-6 (2006)
PMID: 16369486

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147558 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mucin-1 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15941 (Residues: 1041-1097; Coverage: 5%)
Gene names: MUC1, PUM
Sequence domains: SEA domain
Mucin-1 subunit beta Chain: B
Molecule details ›
Chain: B
Length: 55 amino acids
Theoretical weight: 6.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15941 (Residues: 1098-1152; Coverage: 5%)
Gene names: MUC1, PUM
Sequence domains: SEA domain
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Mucins in cancer: function, prognosis and therapy.
Kufe DW. (2009)
45 more

16 mentions without citation

Post-translational regulation of signaling mucins.
Cullen PJ. (2011)
15 more