› 2ado

X-ray diffraction
1.45Å resolution

Crystal Structure Of The Brct Repeat Region From The Mediator of DNA damage checkpoint protein 1, MDC1

Released:
DOI: 10.2210/pdb2ado/pdb
PDB entry 2ado coloured by chain, front view.
PDB entry 2ado coloured by chain, side view.
PDB entry 2ado coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.
Lee MS, Edwards RA, Thede GL, Glover JN
J Biol Chem 280 32053-6 (2005)
PMID: 16049003

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172074 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of DNA damage checkpoint protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 196 amino acids
Theoretical weight: 21.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14676 (Residues: 1891-2086; Coverage: 9%)
Gene names: KIAA0170, MDC1, NFBD1
Sequence domains:
Structure domains: BRCT domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P1
Unit cell:
a: 42.051Å b: 44.44Å c: 61.942Å
α: 72.95° β: 87.54° γ: 61.8°
R-values:
R R work R free
0.195 0.195 0.212
Expression system: Escherichia coli

Quick links

Citations

27 review citations

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
Taverna et al. (2007)
26 more

4 mentions without citation

BRCT domains: easy as one, two, three.
Leung et al. (2011)
3 more