› 2aew

X-ray diffraction
2.7Å resolution

A model for growth hormone receptor activation based on subunit rotation within a receptor dimer

Released:
DOI: 10.2210/pdb2aew/pdb
PDB entry 2aew coloured by chain, front view.
PDB entry 2aew coloured by chain, side view.
PDB entry 2aew coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer.
Brown RJ, Adams JJ, Pelekanos RA, Wan Y, McKinstry WJ, Palethorpe K, Seeber RM, Monks TA, Eidne KA, Parker MW, Waters MJ
Nat Struct Mol Biol 12 814-21 (2005)
PMID: 16116438

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145517 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth hormone-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 205 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10912 (Residues: 47-251; Coverage: 33%)
Gene name: GHR
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: C2221
Unit cell:
a: 99.72Å b: 112.167Å c: 93.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.262 0.257 0.302
Expression system: Escherichia coli

Quick links

Citations

86 review citations

Medical progress: Acromegaly.
Melmed S. (2006)
85 more

4 mentions without citation

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Metcalfe et al. (2020)
3 more