› 2afj

Solution NMR

SPRY domain-containing SOCS box protein 2 (SSB-2)

Released:
DOI: 10.2210/pdb2afj/pdb
PDB entry 2afj coloured by chain, ensemble of 20 models, front view.
PDB entry 2afj coloured by chain, ensemble of 20 models, side view.
PDB entry 2afj coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues.
Masters SL, Yao S, Willson TA, Zhang JG, Palmer KR, Smith BJ, Babon JJ, Nicola NA, Norton RS, Nicholson SE
Nat Struct Mol Biol 13 77-84 (2006)
PMID: 16369487

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SPRY domain-containing SOCS box protein 2 Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 24.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O88838 (Residues: 12-224; Coverage: 81%)
Gene names: Grcc9, Spsb2, Ssb2
Sequence domains: SPRY domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*).
Masters et al. (2009)
15 more

2 mentions without citation

Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops.
Yao et al. (2006)
1 more