› 2amy

X-ray diffraction
2.09Å resolution

X-Ray Structure of Human Phosphomannomutase 2 (PMM2)

Released:
DOI: 10.2210/pdb2amy/pdb
PDB entry 2amy coloured by chain, front view.
PDB entry 2amy coloured by chain, side view.
PDB entry 2amy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wesenberg GE, Phillips Jr GN, McCoy JG, Bitto E, Bingman CA, Allard STM, Center for Eukaryotic Structural Genomics (CESG)

Function and Biology Details

Reaction catalysed: 
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127428 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphomannomutase 2 Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15305 (Residues: 2-246; Coverage: 100%)
Gene name: PMM2
Sequence domains: Eukaryotic phosphomannomutase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand GLY 3 x GLY
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM, APS BEAMLINE 22-ID
Spacegroup: P3221
Unit cell:
a: 70.622Å b: 70.622Å c: 100.15Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.272
Expression system: Escherichia coli

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