› 2ao7

X-ray diffraction
2.9Å resolution

Adam10 Disintegrin and cysteine- rich domain

Released:
DOI: 10.2210/pdb2ao7/pdb
PDB entry 2ao7 coloured by chain, front view.
PDB entry 2ao7 coloured by chain, side view.
PDB entry 2ao7 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
ADAM and Eph: how Ephrin-signaling cells become detached.
Mancia F, Shapiro L
Cell 123 185-7 (2005)
PMID: 16239135

Function and Biology Details

Reaction catalysed: 
Endopeptidase of broad specificity.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-171249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disintegrin and metalloproteinase domain-containing protein 10 Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 20.87 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q10741 (Residues: 455-646; Coverage: 26%)
Gene names: ADAM10, MADM
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: I4132
Unit cell:
a: 146.78Å b: 146.78Å c: 146.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.261 0.261 0.289
Expression system: Homo sapiens

Quick links

Citations

6 review citations

The ADAM metalloproteinases.
Edwards et al. (2008)
5 more

8 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
7 more