› 2arv

X-ray diffraction
2Å resolution

Structure of human Activin A

Released:
DOI: 10.2210/pdb2arv/pdb
PDB entry 2arv coloured by chain, front view.
PDB entry 2arv coloured by chain, side view.
PDB entry 2arv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the inhibition of activin signalling by follistatin.
Harrington AE, Morris-Triggs SA, Ruotolo BT, Robinson CV, Ohnuma S, Hyvönen M
EMBO J 25 1035-45 (2006)
PMID: 16482217

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inhibin beta A chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08476 (Residues: 311-426; Coverage: 29%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

3 bound ligands:
Ligand SO4 4 x SO4
Ligand GOL 3 x GOL
Ligand 1PG 1 x 1PG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: I222
Unit cell:
a: 63.572Å b: 96.247Å c: 118.038Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.259
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

26 review citations

Specificity, versatility, and control of TGF-β family signaling.
Derynck et al. (2019)
25 more

10 mentions without citation

Structural basis for the inhibition of activin signalling by follistatin.
Harrington et al. (2006)
9 more