› 2ask

X-ray diffraction
1.55Å resolution

Structure of human Artemin

Released:
DOI: 10.2210/pdb2ask/pdb
PDB entry 2ask coloured by chain, front view.
PDB entry 2ask coloured by chain, side view.
PDB entry 2ask coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Artemin crystal structure reveals insights into heparan sulfate binding.
Silvian L, Jin P, Carmillo P, Boriack-Sjodin PA, Pelletier C, Rushe M, Gong B, Sah D, Pepinsky B, Rossomando A
Biochemistry 45 6801-12 (2006)
PMID: 16734417

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-178303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Artemin Chains: A, B
Molecule details ›
Chains: A, B
Length: 113 amino acids
Theoretical weight: 11.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5T4W7 (Residues: 108-220; Coverage: 62%)
Gene names: ARTN, EVN
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A, null
Spacegroup: C2
Unit cell:
a: 114.631Å b: 33.674Å c: 55.58Å
α: 90° β: 98.95° γ: 90°
R-values:
R R work R free
0.231 0.221 0.255
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The structure of glycosaminoglycans and their interactions with proteins.
Gandhi et al. (2008)
6 more

6 mentions without citation

The role of glial cell line-derived neurotrophic factor family member artemin in neurological disorders and cancers.
Zhu et al. (2020)
5 more