› 2aug

X-ray diffraction
2.3Å resolution

Crystal structure of the Grb14 SH2 domain

Released:
DOI: 10.2210/pdb2aug/pdb
PDB entry 2aug coloured by chain, front view.
PDB entry 2aug coloured by chain, side view.
PDB entry 2aug coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.
Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR
Mol Cell 20 325-33 (2005)
PMID: 16246733

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172004 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 14 Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 14.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14449 (Residues: 433-537; Coverage: 19%)
Gene name: GRB14
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 49.118Å b: 49.118Å c: 184.087Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.199 0.248

Quick links

Citations

14 review citations

Tyrosine phosphorylation: thirty years and counting.
Hunter T. (2009)
13 more

7 mentions without citation

Receptor tyrosine kinases: mechanisms of activation and signaling.
Hubbard et al. (2007)
6 more