Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- BPS (Between PH and SH2) domain
- Tyrosine-protein kinase, receptor class II, conserved site
- Tyrosine-protein kinase, active site
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, catalytic domain
- Protein kinase domain
- Protein kinase-like domain superfamily
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138938 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin receptor subunit beta
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P06213 (Residues: 1005-1310; Coverage: 23%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Growth factor receptor-bound protein 14
Molecule details ›
Chain: B
Length: 59 amino acids
Theoretical weight: 6.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: BPS (Between PH and SH2)
Length: 59 amino acids
Theoretical weight: 6.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q14449 (Residues: 361-419; Coverage: 11%)
Sequence domains: BPS (Between PH and SH2)
