› 2ax7

X-ray diffraction
1.9Å resolution

Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex With S-1

Released:
DOI: 10.2210/pdb2ax7/pdb
PDB entry 2ax7 coloured by chain, front view.
PDB entry 2ax7 coloured by chain, side view.
PDB entry 2ax7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for accommodation of nonsteroidal ligands in the androgen receptor.
Bohl CE, Miller DD, Chen J, Bell CE, Dalton JT
J Biol Chem 280 37747-54 (2005)
PMID: 16129672

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 665-920; Coverage: 28%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand FHM 1 x FHM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 54.818Å b: 66.371Å c: 69.076Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.247
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Protective actions of sex steroid hormones in Alzheimer's disease.
Pike et al. (2009)
22 more

4 mentions without citation

Structural basis for accommodation of nonsteroidal ligands in the androgen receptor.
Bohl et al. (2005)
3 more