› 2axl

Solution NMR

Solution structure of a multifunctional DNA- and protein-binding domain of human Werner syndrome protein

Released:
DOI: 10.2210/pdb2axl/pdb
PDB entry 2axl coloured by chain, ensemble of 10 models, front view.
PDB entry 2axl coloured by chain, ensemble of 10 models, side view.
PDB entry 2axl coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein.
Hu JS, Feng H, Zeng W, Lin GX, Xi XG
Proc Natl Acad Sci U S A 102 18379-84 (2005)
PMID: 16339893

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171958 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q14191 (Residues: 949-1092; Coverage: 10%)
Gene names: RECQ3, RECQL2, WRN
Sequence domains: RQC domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

12 review citations

SSB as an organizer/mobilizer of genome maintenance complexes.
Shereda et al. (2008)
11 more

4 mentions without citation

Structure of the human RECQ1 helicase reveals a putative strand-separation pin.
Pike et al. (2009)
3 more