› 2axy

X-ray diffraction
1.7Å resolution

Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA

Released:
DOI: 10.2210/pdb2axy/pdb
PDB entry 2axy coloured by chain, front view.
PDB entry 2axy coloured by chain, side view.
PDB entry 2axy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A.
Du Z, Lee JK, Tjhen R, Li S, Pan H, Stroud RM, James TL
J Biol Chem 280 38823-30 (2005)
PMID: 16186123

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115094 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Poly(rC)-binding protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 73 amino acids
Theoretical weight: 8.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15366 (Residues: 11-82; Coverage: 20%)
Gene name: PCBP2
Sequence domains: KH domain
Structure domains: K Homology domain, type 1
C-rich strand of human telomeric dna Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 7 nucleotides
Theoretical weight: 2.07 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21212
Unit cell:
a: 66.603Å b: 115.176Å c: 45.525Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.214 0.238
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

10 review citations

RNA-binding proteins: modular design for efficient function.
Lunde et al. (2007)
9 more

5 mentions without citation

Conformational changes in redox pairs of protein structures.
Fan et al. (2009)
4 more