› 2b3a

Solution NMR

Solution structure of the Ras-binding domain of the Ral Guanosine Dissociation Stimulator

Released:
DOI: 10.2210/pdb2b3a/pdb
PDB entry 2b3a coloured by chain, ensemble of 10 models, front view.
PDB entry 2b3a coloured by chain, ensemble of 10 models, side view.
PDB entry 2b3a coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
New insights into binding of the possible cancer target RalGDS
Gronwald W, Maurer T, Fuechsl R, Wohlgemuth S, Herrmann C, Kalbitzer HR
To be published

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ral guanine nucleotide dissociation stimulator Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 10.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12967 (Residues: 798-884; Coverage: 10%)
Gene names: KIAA1308, RALGDS, RGF
Sequence domains: Ras association (RalGDS/AF-6) domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing first in torsion angle space followed by simulated annealing in cartesian space. Final refinement in explicit solvent (H2O).
Expression system: Escherichia coli BL21(DE3)

Quick links