› 2b4x

X-ray diffraction
2.8Å resolution

Crystal Structure of Antithrombin-III

Released:
DOI: 10.2210/pdb2b4x/pdb
PDB entry 2b4x coloured by chain, front view.
PDB entry 2b4x coloured by chain, side view.
PDB entry 2b4x coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Adams TE, Huntington JA, Johnson DJD, Bock SC

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133777 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Antithrombin-III Chain: I
Molecule details ›
Chain: I
Length: 427 amino acids
Theoretical weight: 48.5 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01008 (Residues: 37-463; Coverage: 99%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Antithrombin-III Chain: L
Molecule details ›
Chain: L
Length: 427 amino acids
Theoretical weight: 48.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 37-463; Coverage: 99%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P21
Unit cell:
a: 68.47Å b: 98.67Å c: 89.24Å
α: 90° β: 105° γ: 90°
R-values:
R R work R free
0.236 0.228 0.283
Expression system: Drosophila melanogaster

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