› 2bdf

X-ray diffraction
2.1Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 279 amino acids
Theoretical weight: 31.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12931 (Residues: 258-536; Coverage: 52%)
Gene names: SRC, SRC1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 24A 2 x 24A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P1
Unit cell:
a: 41.93Å b: 59.74Å c: 63.59Å
α: 93.03° β: 91.43° γ: 97.79°
R-values:
R R work R free
0.206 0.206 0.271
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Flying under the radar: the new wave of BCR-ABL inhibitors.
Quintás-Cardama et al. (2007)
5 more

17 mentions without citation

Three-Dimensional Interactions Analysis of the Anticancer Target c-Src Kinase with Its Inhibitors.
Jha et al. (2020)
16 more