› 2bdn

X-ray diffraction
2.53Å resolution

Crystal structure of human MCP-1 bound to a blocking antibody, 11K2

Released:
DOI: 10.2210/pdb2bdn/pdb
PDB entry 2bdn coloured by chain, front view.
PDB entry 2bdn coloured by chain, side view.
PDB entry 2bdn coloured by chain, top view.
Source organisms:
Primary publication:
Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.
Reid C, Rushe M, Jarpe M, van Vlijmen H, Dolinski B, Qian F, Cachero TG, Cuervo H, Yanachkova M, Nwankwo C, Wang X, Etienne N, Garber E, Bailly V, de Fougerolles A, Boriack-Sjodin PA
Protein Eng Des Sel 19 317-24 (2006)
PMID: 16682434

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210544 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
C-C motif chemokine 2 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.7 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13500 (Residues: 24-99; Coverage: 100%)
Gene names: CCL2, MCP1, SCYA2
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Antibody light chain 11K2 Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.57 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Antibody heavy chain 11K2 Chain: H
Molecule details ›
Chain: H
Length: 217 amino acids
Theoretical weight: 23.12 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2221
Unit cell:
a: 86.36Å b: 89.1Å c: 176.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.219 0.277
Expression systems:
  • Not provided
  • Mus musculus

Quick links

Citations

4 review citations

Monocyte chemoattractant protein-1 (MCP-1): an overview.
Deshmane et al. (2009)
3 more

14 mentions without citation

Practically useful: what the Rosetta protein modeling suite can do for you.
Kaufmann et al. (2010)
13 more