› 2bil

X-ray diffraction
2.55Å resolution

The human protein kinase Pim1 in complex with its consensus peptide Pimtide

Released:
DOI: 10.2210/pdb2bil/pdb
PDB entry 2bil coloured by chain, front view.
PDB entry 2bil coloured by chain, side view.
PDB entry 2bil coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Knapp S, Debreczeni J, Bullock A, von Delft F, Sundstrom M, Arrowsmith C, Edwards A, Guo K

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145754 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CONSENSUS PIM1 PEPTIDE PIMTIDE Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.59 KDa
Source organism: Homo sapiens
Expression system: Not provided
Serine/threonine-protein kinase pim-1 Chain: B
Molecule details ›
Chain: B
Length: 313 amino acids
Theoretical weight: 35.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P11309 (Residues: 1-313; Coverage: 100%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BI1 1 x BI1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P65
Unit cell:
a: 98.1Å b: 98.1Å c: 80.04Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.248
Expression systems:
  • Not provided
  • Escherichia coli BL21

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