› 2bmj

X-ray diffraction
2.1Å resolution

GTPase like domain of Centaurin Gamma 1 (Human)

Released:
DOI: 10.2210/pdb2bmj/pdb
PDB entry 2bmj coloured by chain, front view.
PDB entry 2bmj coloured by chain, side view.
PDB entry 2bmj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The centaurin gamma-1 GTPase-like domain functions as an NTPase.
Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA
Biochem J 401 679-88 (2007)
PMID: 17037982

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99490 (Residues: 402-577; Coverage: 15%)
Gene names: AGAP2, CENTG1, KIAA0167
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: C2
Unit cell:
a: 62.151Å b: 31.104Å c: 81.928Å
α: 90° β: 102.22° γ: 90°
R-values:
R R work R free
0.166 0.163 0.225
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Vigil et al. (2010)
7 more

2 mentions without citation

The centaurin gamma-1 GTPase-like domain functions as an NTPase.
Soundararajan et al. (2007)
1 more