› 2bsr

X-ray diffraction
2.3Å resolution

Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B2705

Released:
DOI: 10.2210/pdb2bsr/pdb
PDB entry 2bsr coloured by chain, front view.
PDB entry 2bsr coloured by chain, side view.
PDB entry 2bsr coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705.
Stewart-Jones GB, di Gleria K, Kollnberger S, McMichael AJ, Jones EY, Bowness P
Eur J Immunol 35 341-51 (2005)
PMID: 15657948

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135130 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Epstein-Barr nuclear antigen 6 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.19 KDa
Source organism: human gammaherpesvirus 4
Expression system: Not provided
UniProt:
  • Canonical: P03204 (Residues: 258-266; Coverage: 1%)
Gene names: BERF3-BERF4, EBNA6

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 51.054Å b: 82.122Å c: 108.719Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.28
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

16 review citations

The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense.
Bashirova et al. (2006)
15 more

6 mentions without citation

Structure and Dynamics of Antigenic Peptides in Complex with TAP.
Lehnert et al. (2017)
5 more