› 2bv1

X-ray diffraction
2Å resolution

Regulator of G-protein Signalling 1 (Human)

Released:
DOI: 10.2210/pdb2bv1/pdb
PDB entry 2bv1 coloured by chain, front view.
PDB entry 2bv1 coloured by chain, side view.
PDB entry 2bv1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP
Proc Natl Acad Sci U S A 105 6457-62 (2008)
PMID: 18434541

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170596 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 145 amino acids
Theoretical weight: 16.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08116 (Residues: 63-205; Coverage: 68%)
Gene names: 1R20, BL34, IER1, RGS1
Sequence domains: Regulator of G protein signaling domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P1
Unit cell:
a: 40.738Å b: 43.202Å c: 58.651Å
α: 78.43° β: 85.3° γ: 69.74°
R-values:
R R work R free
0.191 0.188 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Update on melatonin receptors: IUPHAR Review 20.
Jockers et al. (2016)
22 more

3 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
2 more