› 2byg

X-ray diffraction
1.85Å resolution

2nd PDZ Domain of Discs Large Homologue 2

Released:
DOI: 10.2210/pdb2byg/pdb
PDB entry 2byg coloured by chain, front view.
PDB entry 2byg coloured by chain, side view.
PDB entry 2byg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Elkins JM, Papagrigoriou E, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P, Doyle DA
Protein Sci 16 683-94 (2007)
PMID: 17384233

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172378 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 2 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 12.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15700 (Residues: 190-283; Coverage: 11%)
Gene name: DLG2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: I222
Unit cell:
a: 44.774Å b: 69.081Å c: 73.967Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.196 0.252
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Engineering of recombinant crystallization chaperones.
Koide S. (2009)
5 more

6 mentions without citation

Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein.
Zhang et al. (2007)
5 more