Function and Biology Details
Reactions catalysed:
Myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA
(1a) [acetyl-CoA C-acyltransferase]-S-acyl-L-cyteine + acetyl-CoA = 3-oxoacyl-CoA + [acetyl-CoA C-acyltransferase]-L-cyteine
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149590 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisomal targeting signal 1 receptor
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 33.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Tetratricopeptide repeat
Structure domains: Tetratricopeptide repeat domain
Length: 305 amino acids
Theoretical weight: 33.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P50542 (Residues: 335-639; Coverage: 48%)
Sequence domains: Tetratricopeptide repeat
Structure domains: Tetratricopeptide repeat domain
Sterol carrier protein 2
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: SCP-2 sterol transfer family
Structure domains: SCP2 sterol-binding domain
Length: 122 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P22307 (Residues: 426-547; Coverage: 22%)
Sequence domains: SCP-2 sterol transfer family
Structure domains: SCP2 sterol-binding domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup:
P212121
Expression system: Escherichia coli
