› 2c0m

X-ray diffraction
2.5Å resolution

apo form of the TPR domain of the pex5p receptor

Released:
DOI: 10.2210/pdb2c0m/pdb
PDB entry 2c0m coloured by chain, front view.
PDB entry 2c0m coloured by chain, side view.
PDB entry 2c0m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.
Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M
Mol Cell 24 653-663 (2006)
PMID: 17157249

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisomal targeting signal 1 receptor Chains: A, B, C, F
Molecule details ›
Chains: A, B, C, F
Length: 319 amino acids
Theoretical weight: 35.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50542 (Residues: 321-639; Coverage: 50%)
Gene names: PEX5, PXR1
Sequence domains: Tetratricopeptide repeat
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 53.47Å b: 85.55Å c: 88.89Å
α: 71.17° β: 89.99° γ: 73.43°
R-values:
R R work R free
0.265 0.263 0.309
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Versatile TPR domains accommodate different modes of target protein recognition and function.
Allan et al. (2011)
28 more

10 mentions without citation

Development of Novel Anti-Leishmanials: The Case for Structure-Based Approaches.
Soni et al. (2022)
9 more