› 2c7a

X-ray diffraction
2.5Å resolution

STRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX

Released:
DOI: 10.2210/pdb2c7a/pdb
PDB entry 2c7a coloured by chain, front view.
PDB entry 2c7a coloured by chain, side view.
PDB entry 2c7a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements.
Roemer SC, Donham DC, Sherman L, Pon VH, Edwards DP, Churchill ME
Mol Endocrinol 20 3042-52 (2006)
PMID: 16931575

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115138 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 78 amino acids
Theoretical weight: 8.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06401 (Residues: 563-640; Coverage: 8%)
Gene names: NR3C3, PGR
Sequence domains: Zinc finger, C4 type (two domains)
Structure domains: Erythroid Transcription Factor GATA-1, subunit A
5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*TP *TP*TP*GP*TP*TP*CP*TP*G)-3' Chain: C
Molecule details ›
Chain: C
Length: 18 nucleotides
Theoretical weight: 5.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*AP*AP *CP*TP*GP*TP*TP*CP*TP*G)-3' Chain: D
Molecule details ›
Chain: D
Length: 18 nucleotides
Theoretical weight: 5.48 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 39.53Å b: 107.85Å c: 111.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.198 0.246
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

14 review citations

Nuclear receptor structure: implications for function.
Bain et al. (2007)
13 more

7 mentions without citation

Demystifying the Functional Role of Nuclear Receptors in Esophageal Cancer.
Jayaprakash et al. (2022)
6 more