› 2cfj

Solution NMR

Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity

Released:
DOI: 10.2210/pdb2cfj/pdb
PDB entry 2cfj coloured by chain, ensemble of 10 models, front view.
PDB entry 2cfj coloured by chain, ensemble of 10 models, side view.
PDB entry 2cfj coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Spectroscopic Characterization of Successive Phosphorylation of the Tissue Factor Cytoplasmic Region.
Sen M, Herzik M, Craft JW, Creath AL, Agrawal S, Ruf W, Legge GB
Open Spectrosc J 3 58-64 (2009)
PMID: 20076769

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146728 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tissue factor Chain: A
Molecule details ›
Chain: A
Length: 19 amino acids
Theoretical weight: 2.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13726 (Residues: 277-295; Coverage: 7%)
Gene name: F3

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 75%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Tissue factor at the crossroad of coagulation and cell signaling.
Zelaya et al. (2018)
3 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)