› 2cke

X-ray diffraction
2.8Å resolution

Human death-associated DRP-1 kinase in complex with inhibitor

Released:
DOI: 10.2210/pdb2cke/pdb
PDB entry 2cke coloured by chain, front view.
PDB entry 2cke coloured by chain, side view.
PDB entry 2cke coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kursula P, Wilmanns M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Death-associated protein kinase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 321 amino acids
Theoretical weight: 37.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UIK4 (Residues: 11-330; Coverage: 87%)
Gene name: DAPK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand IQU 4 x IQU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P1
Unit cell:
a: 55.21Å b: 60.48Å c: 99.28Å
α: 92.09° β: 103.39° γ: 94.16°
R-values:
R R work R free
0.206 0.203 0.261
Expression system: Escherichia coli BL21

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