› 2cls

X-ray diffraction
2.31Å resolution

The crystal structure of the human RND1 GTPase in the active GTP bound state

Released:
DOI: 10.2210/pdb2cls/pdb
PDB entry 2cls coloured by chain, front view.
PDB entry 2cls coloured by chain, side view.
PDB entry 2cls coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pike ACW, Yang X, Colebrook S, Gileadi O, Sobott F, Bray J, Wen Hwa L, Marsden B, Zhao Y, Schoch G, Elkins J, Debreczeni JE, Turnbull AP, von Delft F, Arrowsmith C, Edwards A, Weigelt J, Sundstrom M, Doyle D

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187731 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho-related GTP-binding protein Rho6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 198 amino acids
Theoretical weight: 22.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92730 (Residues: 5-200; Coverage: 85%)
Gene names: RHO6, RND1
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand GTP 2 x GTP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 67.168Å b: 67.762Å c: 206.409Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.236
Expression system: Escherichia coli BL21(DE3)

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