› 2cnj

Solution NMR

NMR studies on the interaction of Insulin-Growth Factor II (IGF-II) with IGF2R domain 11

Released:
DOI: 10.2210/pdb2cnj/pdb
PDB entry 2cnj coloured by chain, ensemble of 20 models, front view.
PDB entry 2cnj coloured by chain, ensemble of 20 models, side view.
PDB entry 2cnj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11.
Williams C, Rezgui D, Prince SN, Zaccheo OJ, Foulstone EJ, Forbes BE, Norton RS, Crosby J, Hassan AB, Crump MP
Structure 15 1065-78 (2007)
PMID: 17850746

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cation-independent mannose-6-phosphate receptor Chain: D
Molecule details ›
Chain: D
Length: 151 amino acids
Theoretical weight: 16.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11717 (Residues: 1508-1651; Coverage: 6%)
Gene names: IGF2R, MPRI
Sequence domains: Cation-independent mannose-6-phosphate receptor repeat
Structure domains: Mannose-6-phosphate receptor binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: WATER REFINED IN CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Survey of the year 2007 commercial optical biosensor literature.
Rich et al. (2008)
5 more

1 mention without citation

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Williams et al. (2012)