› 2cok

Solution NMR

Solution structure of BRCT domain of poly(ADP-ribose) polymerase-1

Released:
DOI: 10.2210/pdb2cok/pdb
PDB entry 2cok coloured by chain, ensemble of 20 models, front view.
PDB entry 2cok coloured by chain, ensemble of 20 models, side view.
PDB entry 2cok coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Nagashima T, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase 1, processed C-terminus Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09874 (Residues: 387-486; Coverage: 10%)
Gene names: ADPRT, PARP1, PPOL
Sequence domains: BRCA1 C Terminus (BRCT) domain
Structure domains: BRCT domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links