› 2cq8

Solution NMR

Solution structure of RSGI RUH-033, a pp-binding domain of 10-FTHFDH from human cDNA

Released:
DOI: 10.2210/pdb2cq8/pdb
PDB entry 2cq8 coloured by chain, ensemble of 20 models, front view.
PDB entry 2cq8 coloured by chain, ensemble of 20 models, side view.
PDB entry 2cq8 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Abe T, Hirota H, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131158 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic 10-formyltetrahydrofolate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O75891 (Residues: 305-401; Coverage: 11%)
Gene names: ALDH1L1, FTHFD
Sequence domains: Phosphopantetheine attachment site
Structure domains: ACP-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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