› 2d46

Solution NMR

Solution Structure of the Human Beta4a-A Domain

Released:
DOI: 10.2210/pdb2d46/pdb
PDB entry 2d46 coloured by chain, front view.
PDB entry 2d46 coloured by chain, side view.
PDB entry 2d46 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the N-terminal A domain of the human voltage-gated Ca2+channel beta4a subunit.
Vendel AC, Rithner CD, Lyons BA, Horne WA
Protein Sci 15 378-83 (2006)
PMID: 16385006

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent L-type calcium channel subunit beta-4 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00305 (Residues: 50-92; Coverage: 8%)
Gene names: CACNB4, CACNLB4
Sequence domains: Voltage gated calcium channel subunit beta domain 4Aa N terminal
Structure domains: Ybab; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The ß subunit of voltage-gated Ca2+ channels.
Buraei et al. (2010)
4 more

5 mentions without citation

Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex.
Vendel et al. (2006)
4 more