› 2d4f

X-ray diffraction
1.7Å resolution

The Crystal Structure of human beta2-microglobulin

Released:
DOI: 10.2210/pdb2d4f/pdb
PDB entry 2d4f coloured by chain, front view.
PDB entry 2d4f coloured by chain, side view.
PDB entry 2d4f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis.
Kihara M, Chatani E, Iwata K, Yamamoto K, Matsuura T, Nakagawa A, Naiki H, Goto Y
J Biol Chem 281 31061-9 (2006)
PMID: 16901902

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: C2
Unit cell:
a: 77.649Å b: 28.869Å c: 54.756Å
α: 90° β: 121.66° γ: 90°
R-values:
R R work R free
0.208 0.207 0.233
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Glimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscape.
Platt et al. (2009)
1 more

10 mentions without citation

Understanding the complex mechanisms of β2-microglobulin amyloid assembly.
Eichner et al. (2011)
9 more