› 2d68

X-ray diffraction
1.6Å resolution

Structure of the N-terminal domain of FOP (FGFR1OP) protein

Released:
DOI: 10.2210/pdb2d68/pdb
PDB entry 2d68 coloured by chain, front view.
PDB entry 2d68 coloured by chain, side view.
PDB entry 2d68 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization.
Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA
J Mol Biol 359 863-75 (2006)
PMID: 16690081

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-131984 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Centrosomal protein 43 Chains: A, B
Molecule details ›
Chains: A, B
Length: 82 amino acids
Theoretical weight: 9.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95684 (Residues: 54-135; Coverage: 21%)
Gene names: CEP43, FGFR1OP, FOP
Sequence domains: FOP N terminal dimerisation domain
Structure domains: Mitochondrial Import Receptor Subunit Tom20; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P21212
Unit cell:
a: 47.84Å b: 92.18Å c: 37.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.247
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies.
Medves et al. (2012)
3 more

3 mentions without citation

Crystal structure of the LUFS domain of human single-stranded DNA binding Protein 2 (SSBP2).
Wang et al. (2019)
2 more