› 2d82

Solution NMR

Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association

Released:
DOI: 10.2210/pdb2d82/pdb
PDB entry 2d82 coloured by chain, front view.
PDB entry 2d82 coloured by chain, side view.
PDB entry 2d82 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association.
Resnick-Silverman L, Yan S, Mutjaba S, Liu WJ, Zeng L, Manfredi JJ, Zhou MM
Chem Biol 13 81-90 (2006)
PMID: 16426974

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 14.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand TTR 1 x TTR
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance Geometry, Simulated Annealing
Expression system: Escherichia coli BL21

Quick links

Citations

38 review citations

Targeting bromodomains: epigenetic readers of lysine acetylation.
Filippakopoulos et al. (2014)
37 more

4 mentions without citation

Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.
Andreoli et al. (2013)
3 more