› 2dco

Solution NMR

S1P4 First Extracellular Loop Peptidomimetic

Released:
DOI: 10.2210/pdb2dco/pdb
PDB entry 2dco coloured by chain, ensemble of 10 models, front view.
PDB entry 2dco coloured by chain, ensemble of 10 models, side view.
PDB entry 2dco coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Peptide design and structural characterization of a GPCR loop mimetic.
Pham TC, Kriwacki RW, Parrill AL
Biopolymers 86 298-310 (2007)
PMID: 17443712

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sphingosine 1-phosphate receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95977 (Residues: 105-122; Coverage: 5%)
Gene names: EDG6, S1PR4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, matrix relaxation, torsion angle dynamics, energy minimization
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Lysophospholipid interactions with protein targets.
Parrill AL. (2008)
2 more

5 mentions without citation

Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.
Tikhonova et al. (2009)
4 more