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X-ray diffraction
2.7Å resolution

Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) (orthorhombic form)

Released:
DOI: 10.2210/pdb2ddk/pdb
PDB entry 2ddk coloured by chain, front view.
PDB entry 2ddk coloured by chain, side view.
PDB entry 2ddk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.
Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, Hanawa-Suetsugu K, Yoshikawa T, Shirouzu M, Yokoyama S
Proteins 67 732-42 (2007)
PMID: 17340635

Function and Biology Details

Reaction catalysed: 
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127069 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol monophosphatase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 299 amino acids
Theoretical weight: 32.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14732 (Residues: 1-288; Coverage: 100%)
Gene names: IMP.18P, IMPA2
Sequence domains: Inositol monophosphatase family
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P212121
Unit cell:
a: 65.457Å b: 95.639Å c: 107.239Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.26 0.301
Expression system: Escherichia coli

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Citations

2 review citations

Translating neurotrophic and cellular plasticity: from pathophysiology to improved therapeutics for bipolar disorder.
Soeiro-de-Souza et al. (2012)
1 more