› 2dgz

Solution NMR

Solution structure of the Helicase and RNase D C-terminal domain in Werner syndrome ATP-dependent helicase

Released:
DOI: 10.2210/pdb2dgz/pdb
PDB entry 2dgz coloured by chain, ensemble of 20 models, front view.
PDB entry 2dgz coloured by chain, ensemble of 20 models, side view.
PDB entry 2dgz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Abe C, Muto Y, Inoue M, Kigawa T, Terada T, Shirouzu M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171958 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.08 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: Q14191 (Residues: 1140-1239; Coverage: 7%)
Gene names: RECQ3, RECQL2, WRN
Sequence domains: HRDC domain
Structure domains: HRDC domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics,restrainted molecular dynamics
Expression system: Cell free synthesis

Quick links