Function and Biology Details
Reactions catalysed:
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine-(R)-S-oxide + NADP(+) + H(2)O
NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
[F-actin]-monooxygenase MICAL1 (preferred)
PDBe Complex ID:
PDB-CPX-186227 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
[F-actin]-monooxygenase MICAL1
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 12.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain
Length: 118 amino acids
Theoretical weight: 12.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q8TDZ2 (Residues: 506-614; Coverage: 10%)
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
simulated annealing
molecular dynamics
torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)
