› 2dm0

Solution NMR

Solution structure of the SH2 domain of human Tyrosine-protein kinase TXK

Released:
DOI: 10.2210/pdb2dm0/pdb
PDB entry 2dm0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2dm0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2dm0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Endo H, Hayashi F, Yoshida M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase TXK Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: P42681 (Residues: 140-251; Coverage: 21%)
Gene names: PTK4, RLK, TXK
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Cell free synthesis

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