› 2dn8

Solution NMR

Solution Structure of RSGI RUH-053, an Apo-Biotin Carboxy Carrier Protein from Human Transcarboxylase

Released:
DOI: 10.2210/pdb2dn8/pdb
PDB entry 2dn8 coloured by chain, ensemble of 20 models, front view.
PDB entry 2dn8 coloured by chain, ensemble of 20 models, side view.
PDB entry 2dn8 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Ruhul Momen AZM, Hirota H, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126388 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-CoA carboxylase 2 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 10.57 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: O00763 (Residues: 885-971; Coverage: 4%)
Gene names: ACACB, ACC2, ACCB
Sequence domains: Biotin-requiring enzyme
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Cell free synthesis

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