› 2dne

Solution NMR

Solution Structure of RSGI RUH-058, a lipoyl domain of human 2-oxoacid dehydrogenase

Released:
DOI: 10.2210/pdb2dne/pdb
PDB entry 2dne coloured by chain, ensemble of 20 models, front view.
PDB entry 2dne coloured by chain, ensemble of 20 models, side view.
PDB entry 2dne coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Ruhul Momen AZM, Hirota H, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine
Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145326 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: P10515 (Residues: 92-186; Coverage: 15%)
Gene names: DLAT, DLTA
Sequence domains: Biotin-requiring enzyme
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Cell free synthesis

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