› 2dvj

Solution NMR

phosphorylated Crk-II

Released:
DOI: 10.2210/pdb2dvj/pdb
PDB entry 2dvj coloured by chain, front view.
PDB entry 2dvj coloured by chain, side view.
PDB entry 2dvj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
Kobashigawa Y, Sakai M, Naito M, Yokochi M, Kumeta H, Makino Y, Ogura K, Tanaka S, Inagaki F
Nat Struct Mol Biol 14 503-10 (2007)
PMID: 17515907

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adapter molecule crk Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 25.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46108 (Residues: 1-228; Coverage: 75%)
Gene name: CRK
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

18 review citations

The ErbB/HER family of protein-tyrosine kinases and cancer.
Roskoski R. (2014)
17 more

4 mentions without citation

Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.
Seo et al. (2009)
3 more