› 2dvv

X-ray diffraction
1.8Å resolution

Crystal structure of the second bromodomain of the human Brd2 protein

Released:
DOI: 10.2210/pdb2dvv/pdb
PDB entry 2dvv coloured by chain, front view.
PDB entry 2dvv coloured by chain, side view.
PDB entry 2dvv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Padmanabhan B, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 13.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 348-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P21212
Unit cell:
a: 71.782Å b: 52.604Å c: 32.059Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.188 0.239
Expression system: Escherichia coli

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