› 2dwb

X-ray diffraction
2.5Å resolution

Aurora-A kinase complexed with AMPPNP

Released:
DOI: 10.2210/pdb2dwb/pdb
PDB entry 2dwb coloured by chain, front view.
PDB entry 2dwb coloured by chain, side view.
PDB entry 2dwb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kukimoto-Niino M, Murayama K, Shirouzu S, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14965 (Residues: 122-403; Coverage: 70%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand ANP 1 x ANP
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P6122
Unit cell:
a: 81.473Å b: 81.473Å c: 174.183Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.227 0.275
Expression system: Not provided

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