› 2dyb

X-ray diffraction
3.15Å resolution

The crystal structure of human p40(phox)

Released:
DOI: 10.2210/pdb2dyb/pdb
PDB entry 2dyb coloured by chain, front view.
PDB entry 2dyb coloured by chain, side view.
PDB entry 2dyb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding.
Honbou K, Minakami R, Yuzawa S, Takeya R, Suzuki NN, Kamakura S, Sumimoto H, Inagaki F
EMBO J 26 1176-86 (2007)
PMID: 17290225

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172189 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil cytosol factor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 39.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15080 (Residues: 1-339; Coverage: 100%)
Gene names: NCF4, SH3PXD4
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CAF 2 x CAF

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: C2221
Unit cell:
a: 146.273Å b: 189.813Å c: 79.883Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.263 0.263 0.302
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Sumimoto H. (2008)
10 more

9 mentions without citation

Translation of the phosphoinositide code by PI effectors.
Kutateladze TG. (2010)
8 more