› 2e50

X-ray diffraction
2.3Å resolution

Crystal structure of SET/TAF-1beta/INHAT

Released:
DOI: 10.2210/pdb2e50/pdb
PDB entry 2e50 coloured by chain, front view.
PDB entry 2e50 coloured by chain, side view.
PDB entry 2e50 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity.
Muto S, Senda M, Akai Y, Sato L, Suzuki T, Nagai R, Senda T, Horikoshi M
Proc Natl Acad Sci U S A 104 4285-90 (2007)
PMID: 17360516

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169522 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protein SET Chains: A, B, P, Q
Molecule details ›
Chains: A, B, P, Q
Length: 225 amino acids
Theoretical weight: 26.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01105 (Residues: 25-238; Coverage: 74%)
Gene name: SET
Sequence domains: Nucleosome assembly protein (NAP)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A, PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21
Unit cell:
a: 60.913Å b: 64.435Å c: 124.421Å
α: 90° β: 90.85° γ: 90°
R-values:
R R work R free
0.22 0.218 0.271
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Histone chaperones: an escort network regulating histone traffic.
De Koning et al. (2007)
24 more

24 mentions without citation

Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis.
Lau et al. (2019)
23 more